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Having recognized the palmitoylation motif of APLNR, we built a short substrate sequence to competitively inhibit the palmitoylation of endogenous APLNR. This aggressive peptide, which targets the APLNR palmitoylation web site in combination with morphine, can inhibit the development of NCP, like pain incidence, microglial activation, and inflammat
Then again, the inflammatory mediators may also encourage the antidromic launch of the transmitters in the collateral branches of the afferent nerves, which is often often called neurogenic inflammation. Neurogenic inflammation occurs when inflammatory mediators, like SP, CGRP and neurokinin (NK), are introduced locally via the afferent neurons. Th